Table 2 Morphologic features of the tumors and correlation with BLBCs

Mitotic number

Mean: 11.5±9

Mean: 25±9

Mean: 10±8

p<0.0001

1.17 (1.12-1.21)

Median: 9

Median: 24

Median: 8

Range: 1-60

Range: 8-60

Range: 1-48

0-7

219 (43.8%)

0 (0%)

219 (48.3%)

8-14

131 (26.2%)

3 (6.4%)

128 (28.3%)

≥15

150 (30%)

44 (93.6%)

106 (23.4%)

Tubule formation

p<0.0001

13.38 (4.31-44.69)

1

36 (7.2%)

0 (0%)

36 (8%)

2

203 (40.6%)

3 (6.4%)

200 (44.1%)

3

261 (52.2%)

44 (93.6%)

217 (47.9%)

Nuclear grade

p<0.0001

42.80 (5.92-309.27)

1

54 (10.8%)

0 (0%)

54 (11.9%)

2

192 (38.4%)

1 (2.1%)

191 (42.2%)

3

254 (50.8%)

46 (97.9%)

208 (45.9%)

Central scar

p=0.68

Present

157 (31.4%)

16 (34%)

141 (31.1%)

Absent

343 (68.6%)

31 (66%)

312 (68.9%)

Central necrosis

p<0.0001

10.08 (5.24-19.38)

Present

104 (20.8%)

31 (66%)

73 (16.1%)

Absent

396 (79.2%)

16 (34%)

380 (83.9%)

Geographic necrosis

p<0.0001

5.23 (2.73-10.02)

Present

71 (14.2%)

19 (40.4%)

52 (11.5%)

Absent

429 (85.8%)

28 (59.6%)

401 (88.5%)

CIS

p<0.0001

5.29 (2.84-9.86)

Present

382 (76.2%)

20 (42.6%)

361 (79.7%)

Absent

119 (23.8%)

27 (57.4%)

92 (20.3%)

Stromal lymphocytic response

p<0.0001

27.02 (8.71-83.92)

None

174 (34.8%)

4 (8.5%)

170 (37.5%)

Mild

158 (31.6%)

4 (8.5%)

154 (34%)

Moderate

114 (22.8%)

18 (38.3%)

96 (21.2%)

Marked

54 (10.8%)

21 (44.7%)

33 (7.3%)

Tumor growth

p<0.0001

7.14 (3.80-13.42)

Pushing

99 (20%)

27 (57.5%)

72 (15.9%)

Infiltrative

401 (80%)

20 (42.6%)

381 (84.1%)

Prominent nucleol

p<0.0001

10.36 (4.31-24.91)

Present

221 (44.2%)

41 (87.2%)

180 (39.7%)

Absent

279 (55.8%)

6 (12.8%)

273 (60.3%)

Vesicular chromatin

p<0.0001

15.59 (6.47-37.59)

Present

179 (35.8%)

41 (87.2%)

138 (30.5%)

Absent

321 (64.2%)

6 (12.8%)

315 (69.5%)

Amount of cytoplasm

p=0.27

Scant

191 (38.2%)

15 (31.9%)

176 (38.8%)

Moderate

132 (26.4%)

15 (31.9%)

162 (35.8%)

Copicious

177 (35.4%)

17 (36.2%)

115 (25.4%)