Fig. 3

Effect of miR-324-5p on cell proliferation, apoptosis, migration and invasion in AGS and MKN45 cell lines. a. miR-324-5p expression was upregulated by the miR-324-5p mimic and downregulated by the miR-324-5p inhibitor in GCa cells. b. The overexpression of miR-324-5p enhanced cell proliferation, but the silencing of miR-324-5p inhibited cell proliferation in both the AGS and MKN45 cell lines. c. miR-324-5p overexpression led to reduced cell apoptosis, but miR-324-5p reduction resulted in increased cell apoptosis in both AGS and MKN45 cell lines. d. The migration ability of both two GCa cell lines was promoted by the overexpression of miR-324-5p, but was suppressed by the knockdown of miR-324-5p. e. The invasion of AGS and MKN45 cells was accelerated by the upregulation of miR-324-5p while inhibited by the downregulation of miR-324-5p. *P < 0.05, **P < 0.01, ***P < 0.001