miR-3113-5p, miR-223-3p, miR-133a-3p, and miR-499a-5p are sensitive biomarkers to diagnose sudden cardiac death

Diagnostic Pathology

Table 1 Basic information regarding the human fatal cases

Cause of death	Group	n	Male/female	Age (years)	Postmortem Interval (h)	heart weight (g)	Survival time (h)
CO intoxication	Positive control	14	7/7	30.29 ± 3.11	7.29 ± 1.92	298.9 ± 32.71	1.58 ± 0.57
Fatal injury	Negative control	14	9/5	45.00 ± 4.01^**	8.07 ± 1.96	312.5 ± 20.18	1.41 ± 0.65
SCD-positive autopsy	SCD	16	14/2	62.69 ± 3.06^***##	3.75 ± 0.66^#	455.6 ± 10.49^***###	1.99 ± 0.93
SCD-negative autopsy	SCD	18	14/4	42.11 ± 3.08^*&&&	5.50 ± 1.27	377.8 ± 27.32^&	1.89 ± 0.58

CO Carbon monoxide. SCD Sudden cardiac death. SCD-positive autopsy, sudden cardiac death with positive autopsy (with evidence of heart dysfunction) findings. SCD-negative autopsy, sudden cardiac death with negative autopsy (without gross heart changes at autopsy) findings
^*p < 0.05, ^**p < 0.01, and ^***p < 0.001 vs. CO intoxication. ^#p < 0.05, ^##p < 0.01, and ^###p < 0.001 vs. Fatal injury. ^&p < 0.05 and ^&&&p < 0.001 vs. SCD-positive autopsy

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