Fig. 2

Images from well-differentiated MDA (B), arising on the base of LEGH (A) with centrally dilated duct surrounded by small proliferating glands. B. MDA with intraluminal papillary infoldings lined by columnar pale cells with abundant mucin, distinct cell borders and very mild nuclear enlargement. C. Focus on stromal invasion by single and small clusters of neoplastic cells. D. HE of moderately-differentiated GAS with columnar pale to eosinophilic cells with nuclear enlargement, stratification and hyperchromasia. Dispersed goblet cells are present Single images of IHC with different antibodies E. CEA, F. MUC-6 G.p16 H.p53 and I.CDX2