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Fig. 2 | Diagnostic Pathology

Fig. 2

From: A second hit somatic (p.R905W) and a novel germline intron-mutation of TSC2 gene is found in intestinal lymphangioleiomyomatosis: a case report with literature review

Fig. 2

A The tumor is well-demarcated, with masses along the intestinal wall. B, C On sectioning and low power view, the tumor appears to replace the proper muscle layer of the cecum with central suppurative necrosis. D High power view of the tumor shows spindle shape mesenchymal cells with slit-like lymphatic channels. The tumor cells show little nuclear atypia. E, F The tumor cells are positive for HMB45 and D2–40. G Tumor is focally positive for smooth muscle actin (SMA). H Ki-67 index is 7.0%. Above mentioned pathological and immunohistochemical features are consistent with LAM. (A, B: gross picture, C, D: H&E, E: HMB45, F: D2–40, G: SMA, H: Ki-67, lower bar: C = 2.5 mm, D = 200 μm, E = 5 mm, F,G: 200 μm, H = 100 μm). LAM, lymphangioleiomyomatosis

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