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Table 4 Correlation between lymphocyte subsets, thyroid function index and lymph node metastasis of PTC patients

From: T cell exhaustion is associated with the risk of papillary thyroid carcinoma and can be a predictive and sensitive biomarker for diagnosis

 

N0 (n = 83)

N1 (n = 49)

P

Total T(%)

63.17 ± 7.26

62.92 ± 9.59

0.877

CD3+CD4+(%)

36.58 ± 6.41

37.50 ± 6.60

0.436

CD3+CD8+(%)

23.28 ± 6.27

22.07 ± 7.44

0.321

CD4+/CD8+(%)

1.64 [1.24,2.12]

1.76 [1.23,2.32]

0.382

CD4+ HLA-DR+(%)

6.06 ± 2.05

6.16 ± 2.14

0.802

CD8+ HLA-DR+(%)

6.70 [4.60,9.05]

6.00 [3.60,7.30]

0.059

CD8+CD38+(%)

4.80 [3.40,6.45]

5.40 [3.50,8.60]

0.084

NK(%)

17.81 ± 7.46

17.26 ± 9.59

0.715

B(%)

14.76 ± 4.75

15.01 ± 5.33

0.776

T3(nmol/L)

1.18 ± 0.22

1.20 ± 0.23

0.596

T4(nmol/L)

8.30 [7.15,9.15]

8.00 [7.30,8.80]

0.606

FT3(pmol/L)

3.38 [3.14,3.52]

3.37 [3.20,3.57]

0.655

FT4(pmol/L)

1.33 ± 0.20

1.31 ± 0.17

0.670

TSH (μIU/mL)

1.65 ± 0.92

1.71 ± 1.01

0.766

TGAb (IU/mL)

25.00 [15.50,78.00]

22.00 [15.00,52.00]

0.363

TPO (IU/mL)

37.00 [28.00,74.00]

30.00 [28.00,52.00]

0.188

CD3+ PD-1+ (%)

10.76 ± 4.68

12.63 ± 4.52

0.026*

CD3+CD4+PD-1+ (%)

7.27 ± 3.01

8.98 ± 3.24

0.003*

CD3+CD8+PD-1+ (%)

4.66 ± 1.81

5.29 ± 2.73

0.156

  1. * represents significant differences (p < 0.05)