Table 3 Literature review of 33 cases of concomitant IPMN and NEN
Case No. | IPMN grading | NEN grading | Morphological classification | Molecular studies | Follow-up | Ref |
|---|---|---|---|---|---|---|
1 | High | NA | Concurrent | NA | NA | Marrache et al., 2005 [13] |
2–6 | Low | NA | Concurrent | NA | NA | Marrache et al., 2005 [13] |
7 | Invasive | NA | Concurrent | NA | Uneventful 10 months after the surgery | Goh et al., 2006 [14] |
8 | Invasive | NA | Concurrent | NA | Uneventful 70 months after the surgery | Goh et al., 2006 [14] |
9 | Low | NA | Concurrent | NA | Uneventful 5 months after the surgery | Goh et al., 2006 [14] |
10 | NA | G1 | Concurrent | NA | NA | Tewari et al., 2013 [15] |
11 | Low | G1 | Concurrent | NA | NA | Ishida et al., 2013 [16] |
12 | Low | NA | Collision | NA | Uneventful | Mortele et al., 2009 [17] |
13 | Low | G1 | Collision | NA | Uneventful 18 months after the surgery | Kadota et al., 2013 [18] |
14 | Invasive | G2 | Collision | NA | Uneventful 5 years after the surgery | Ishizu et al., 2016 [19] |
15 | High | NEC | Collision or composite | NA | Dead 10 months after the surgery | Stukavec et al., 2007 [20] |
16 | Invasive | G2 | Collision or composite | Cytogenetic analysis of LOH | NA | Moriyoshi et al., 2013 [21] |
17–20 | Low | NA | NA | NA | NA | Gill et al., 2009 [22] |
21 | NA | NA | NA | NA | Uneventful for 1 year (follow up without surgery) | Larghi et al., 2009 [23] |
22 | NA | NA | NA | NA | Uneventful | Larghi et al., 2009 [23] |
23 | Invasive | NEC | NA | Testing for KRAS | NA | Tewari et al., 2013 [15] |
24 | High | NEC | NA | Testing for KRAS | NA | Tewari et al., 2013 [15] |
25–29 | NA | NA | NA | NA | NA | Sahora et al., 2016 [24] |
30 | NA | NA | NA | NA | Uneventful for 1 year (follow up without surgery) | Costa et al., 2017 [25] |
31 | Invasive | NEC | Composite | NA | Dead 6 months after the surgery | Hashimoto et al., 2008 [26] |
32 | High | G1 | Composite | Direct sequencing of KRAS | Uneventful 1 year after the surgery | Igarashi et al., 2019 [27] |
33 | High | G2 | Composite | NGS; FISH for CCND1 | Uneventful 27 months after the surgery | Schiavo Lena et al., 2020 [6] |
Our case | Low | G1 | Composite | NGS | Uneventful 21 months after the surgery |  |