Table 4 Correlation between the presence or absence of loss of MMR protein expression with parameters of influence in the different tumors
From: Morphological predictors for microsatellite instability in urothelial carcinoma
Factor | Loss of MMR protein expression | P-value | ||
|---|---|---|---|---|
Yes | No | |||
Age | < 49 years | 0.0% | 100.0% | N.S. |
50–59 years | 11.1% | 88.9% | ||
60–69 years | 10.9% | 89.1% | ||
70–79 years | 6.1% | 93.9% | ||
> 80 years | 12.0% | 88.0% | ||
Sex | Male | 22.2% | 77.8% | < 0.001 |
Female | 3.2% | 96.8% | ||
Localization | Bladder | 7.7% | 92.3% | 0.001 |
Urethra | 0.0% | 100.0% | ||
Ureter | 50% | 50% | ||
Histology of the tumor | Papillary | 11.5% | 88.5% | N.S. |
Mixted | 5.3% | 94.7% | ||
Solid | 11.8% | 88.2% | ||
Urothelial carcinoma with squamous differentiation | 0.0% | 100.0% | ||
Classification of tumor staging | No infiltration | 14.3% | 85.7% | 0.006 (LP) |
Infiltration of lamina propia | 1.4% | 98.6% | < 0.001 (TP) | |
Infiltration of muscle | 13.3% | 86.7% | N.S. | |
Infiltration of perivesical tissue | 40.0% | 60.0% | N.S. | |
Infiltration of other organs | 0.0% | 100.0% | N.S. | |
Histologic grade | Low | 10.2% | 89.8% | N.S. |
High | 8.8% | 91.2% | ||
Tumor necrosis or evident apoptosis. | Yes | 5.4% | 94.6% | 0.088 |
No | 13.8% | 86.2% | ||
Growth pattern | Endophytic | 8.4% | 91.6% | N.S. |
Exophytic | 15.0% | 85.0% | ||
Presence of nucleolus | No | 13.3% | 86.7% | N.S. |
Yes + | 6.5% | 93.5% | ||
Yes ++ | 3.0% | 97.0% | ||
Lymphovascular invasion | Yes | 33.3% | 66.7% | N.S. |
No | 8.8% | 91.2% | ||
Neural invasion | Yes | 9.4% | 90.6% | N.S. |
No | 9.4% | 90.6% | ||
Presence of peritumoral lymphocytes | 0–5% | 55.30% | 44.40% | N.S. |
6–30% | 39.10% | 35.70% | ||
> 30% | 12.80% | 19.80% | ||
Presence of intratumoral lymphocytes | 0–5% | 92.30% | 84.90% | N.S. |
6–20% | 0.00% | 11.10% | ||
> 20% | 7.70% | 4.00% | ||