Fig. 4From: Diagnostic utility of CSF1 immunohistochemistry in tenosynovial giant cell tumor for differentiating from giant cell-rich tumors and tumor-like lesions of bone and soft tissue Histology and CSF1 IHC of undifferentiated pleomorphic sarcoma, leiomyosarcoma, and myxofibrosarcoma a. Undifferentiated pleomorphic sarcoma showed a solid proliferation of atypical spindle to pleomorphic cells with marked nuclear atypia and nuclear pleomorphism b. The tumor cells were negative for CSF1. c. Leiomyosarcoma was composed of a fascicular proliferation of eosinophilic spindle cells with cigar-like elongated nuclei d. The tumor cells were negative for CSF1. e. Myxofibrosarcoma was composed of a fascicular proliferation of atypical spindle cells with vesicular nuclei with moderate to severe nuclear pleomorphism. The background was myxoid f. The tumor cells were negative for CSF1.Back to article page