Fig. 3
From: Completing the view – histologic insights from circular AAA specimen including 3D imaging
Patient 1 sample acquisition, histomorphology and immunohistochemistry left anterior wall (III) and dorsal wall (VIII). CT-angiogram and dotted lines demonstrate the approx. site of samples acquisition. Histologic and immunohistochemistry photos show a representative cutout from the same position of the specimen for HE, EVG and various antibody stainings. Specific histologic features observed include: A fragmented elastic fibers, B collagen deposition/medial fibrosis, C calcification, E mononuclear inflammatory cell infiltration, F thrombus coverage and H mucoid deposition. CD 68 positive cells are seen around the intramural plaque (upper panel) but also in the ILT (lower panel). CD 3 positive cells are located in proximity to the plaque, whereas CD45 positive cells are seen in and close to the ILT. For all histologic photos the aortic lumen is oriented upwards. All samples are presented in the same orientation (A = anterior, P = posterior, R = right, L = left, H = head, T = tail) (scale bar 200 µm; cutouts 50 µm)