Cervical lymphoepithelioma-like carcinoma with deficient mismatch repair and loss of SMARCA4/BRG1: a case report and five related cases

Table 1 Pathological findings in six LEC cases

Case	Age (years)	Specimen	Gross appearance	Architecture	MMR status *	SWI/SNF complex subunit **	CD4	CD8	CD20	PD-L1 TPS	High-risk HPV ISH***	EBER ISH	FIGO 2018 Stage	Initial treatment	Outcome
Present case 1	34	Conization	Exophytic	Solid > Lace-like	Deficient (MLH1, PMS2)	Lost (BRG1)	Mild	Marked	Mild	80	+ (RNA)	-	IB2	Conization and Hysterectomy	NED, 1 year 5 months
2	39	Biopsy	Endophytic	Lace-like > Solid	Deficient (MLH1, PMS2)	Retained	Moderate	Marked	Mild	60	+ (RNA)	-	IIIC1	CCRT	NED, 4 years
3	60	Biopsy	Endophytic	Solid	Proficient	Retained	Mild	Marked	Mild	10	+ (DNA)	-	IIB	CCRT	NED, 6 years
4	80	Excisional biopsy	Exophytic	Lace-like > solid	Proficient	Retained	Mild	Marked	Mild	10	+ (DNA)	-	IB1	None	Vaginal recurrence, 6 years
5	68	Biopsy	Endophytic	Lace-like	Proficient	Retained	Moderate	Marked	Mild	15	+ (DNA)	-	IIB	CCRT	NED, 4 years 5 months
6	68	Biopsy	Exophytic	Solid	Proficient	Retained	Mild	Marked	Mild	10	+ (DNA)	-	IB1	None	Unknown

CCRT, concomitant chemoradiotherapy; EBER, Epstein-Barr virus-encoded small RNA; FIGO, International Federation of Gynecology and Obstetrics; PD-L1, programmed cell death-ligand 1; TPS, total positive score; SMARCA4, switch/sucrose non-fermentable family related, matrix associated, actin dependent regulator of chromatin, subfamily, member 4; SWI/SNF, switch/sucrose non-fermentable
* Immunohistochemical results for MLH1, PMS2, MSH2, and MSH6
** Immunohistochemical results of BRG1/SMARCA4, INI1/SMARCB1 and ARID1A
*** TPS was assessed based on The VENTANA PD-L1 (SP263) Scoring Algorithm (VENTANA PD-L1 (SP263) Assay Staining of Non-Small Cell Lung Cancer Interpretation Guide
**** DNA or RNA

ISSN: 1746-1596