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Table 1 Selected clinical data for 36 COVID-19 autopsy brain cases

From: Acute neutrophilic vasculitis (leukocytoclasia) in 36 COVID-19 autopsy brains

Case no.

Age (yr)/Sex

Major comorbidities

BMIa

D-dimerb

Ventilator (da)

COVID-19–related treatment

Survival (da)/time of death (hr)

1c, d

67/M

DM2

20.1

N/R

Acutely

N/R

0.021/0530

2c

61/F

N/R

N/R

N/R

Acutely

N/R

0.035/1316

3

44/M

HIV, HCV, TB, head injury several months previously

25.1

N/R

Acutely

N/R

0.063/0543

4

84/F

HTN, IHD, arthritis, dementia, chronic venous stasis

23.4

N/R

Acutely

N/R

0.09/1408

5

47/F

HTN, DM

N/R

N/R

Acutely

N/R

0.167/1728

6

72/F

Obesity, influenza A

43

N/R

Acutely

N/R

0.25/1245

7

49/M

HTN, obesity, SAD, BD

34.9

6.9 FEU

1

N/R

1/1404

8

61/M

HTN, IHD, COPD, ethanol abuse

22

620 DDU

2

DEX, REM

4/0511

9

76/F

HTN, DM, IHD, HIV

25.9

326 DDU

None

DEX

5/0444

10c

37/M

HTN, HCV, HPV, hepatocellular carcinoma, SAD

26

N/R

None

N/R

5/0744

11c

49/F

HTN, obesity

67.2

N/R

3

DEX, TOC

8/2340

12

61/F

IHD, COPD, emphysema, asthma, rectal carcinoma

22.7

167 DDU

8

DEX

8/0243

13

64/F

HTN, DM2, old stroke, obesity

34.6

N/R

2

N/R

10/1350

14

65/M

HTN, DM, IHD, COPD, pulmonary fibrosis, obesity

32.6

2551 DDU

< 1

DEX, REM

10/1330

15

63/M

HTN, atrial fibrillation, obesity

46.1

45144 DDU

12

DEX, VAN

12/2025

16c

53/F

HTN, DM2, COPD, pulmonary hypertension, emphysema, obesity

47

N/R

None

TOC

13/1818

17c

58/F

HTN, DM, IHD, obesity, atrial fibrillation, CRD

52

N/R

5

None

16/1749

18

61/F

HTN, DM2, obesity

51.4

2528 DDU

17

DEX

17/1957

19

68/M

HTN, DM2, CRD, anemia of chronic disease

21.8

2574 DDU

None

DEX

19/1100

20

62/F

HTN, DM2, IHD, bilateral carotid artery stenosis, obesity, HCV, hypothyroidism

36.8

523 DDU

5

DEX, REM

19/0437

21

69/F

HTN, DM2, IHD, obesity, CRD

44.5

2462 DDU

11

DEX, REM

22/0708

22e

56/F

HTN, DM, IHD, COPD, asthma, obesity, blood clotting disorder, DVT, liver disease, CRD

45.4

N/R

None

DEX, REM

23/0914

23

73/F

DM2

29

2805 DDU

7

DEX, REM, TOC

24/1033

24

59/F

IHD, remote head trauma, small recent and intermediate cerebral infarcts, small intermediate/remote cerebellar infarcts

21.1

51317 DDU

None

DEX

26/0248

25

70/M

HTN, DM2, IHD, obesity, COPD, asbestosis, obesity, CRD

77.0

527 DDU

23

DEX, REM

27/0322

26

61/M

N/R

20.7

8.07 FEU

28

DEX, REM

29/0423

27

63/M

HTN, DM2, IHD, SAD, HBV, HCV, schizophrenia, BD, hepatic cirrhosis

21.4

N/R

2, later 5, later 9

N/R

29/1654

28c

66/M

HTN, HBV, hepatic cirrhosis

28.3

2884 DDU

13

DEX, REM

33/2108

29e

63/M

HTN, DM, IHD, COPD, asbestosis, TTRA, HIV, HCV, recent left-sided weakness, CRD, hepatic cirrhosis

21.8

1450 DDU

None

N/R

35/2345

30

34/F

DM, obesity

58.5

N/R

10, then 20

N/R

36/2159

31e

62/M

HTN, DM2, DVT, BD, seizure history

24.8

21604 DDU

13, later 15

DEX, REM

39/1514

32

66/F

HTN, obesity, schizophrenia, gout

40.2

252 DDU

18

DEX, REM, TOC

39/0724

33

64/F

COPD, obesity, colon cancer

36

0.62 FEU

24

DEX, REM

41/1800

34

52/F

HTN, IHD, obesity

54.6

5507 DDU

18

DEX

44/1138

35

32/M

DM

23.1

N/R

44

DEX, REM

56/0717

36

64/F

HTN, obesity, schizophrenia, ulcerative colitis

33.3

962 DDU

2, then 32

DEX, CP

84/2152

  1. Case data are arranged in order of increasing time of survival (days)
  2. BMI Body mass index; DM2 DM type 2; N/R None recorded; HIV Human immunodeficiency virus infection; HCV Hepatitis C virus infection; TB Tuberculosis; HTN Systemic hypertension; IHD Ischemic heart disease; DM Diabetes mellitus untyped; COPD Chronic obstructive pulmonary disease; DEX Dexamethasone; REM Remdesivir; SAD Substance abuse disorder; BD Bipolar disorder; HPV Human papillomavirus infection; IV Intravenous; TOC Tocilizumab; CRD Chronic renal disease; DVT Deep vein thrombosis; HBV Hepatitis B virus infection; TTRA Transthyretin amyloidosis; CP Convalescent plasma
  3. aBMI ratio (kg/m2) is 18.5 to 24.9 in most normal adults; obesity, ≥ 30
  4. bD-dimer testing uses either the D-dimer unit reference range (normal, < 250 ng/mL DDU) or the fibrinogen-related reference range (normal, < 0.5 mg/L FEU)
  5. cSARS-CoV-2 delta variant (PCR analysis)
  6. dReceived two doses of vaccine against SARS-CoV-2
  7. eReceived one dose of vaccine against SARS-CoV-2