Table 2 Vascular sites of polymorphonuclear nuclear (PMN) karyorrhexis and acute perivasculitis in 36 COVID-19 autopsy brains
From: Acute neutrophilic vasculitis (leukocytoclasia) in 36 COVID-19 autopsy brains
Case no. | CNS microcirculatory intravascular PMN karyorrhexis/acute endotheliitis | Acute perivasculitis |
|---|---|---|
1 | L thalamus, L int capsule | None |
2 | L frontal lobe, parietal lobes, R lat temp lobe, R insula, L calcarine cortex, L med hypothalamus, R int capsule, R lent nuc, cblr inf vermis, rostral and mid-level pons | Mid-level pons |
3 | Cblr inf vermis, R midbrain teg, L pontine teg, bulbar nuc of spinal tract of nerve V, nuc cuneatus | None |
4 | R occipital lobe, L basal ganglia, rostral R midbrain, caudal L midbrain, rostral pons, mid pons, caudal pons | Rostral L midbrain teg |
5 | R parietal lobe, med and lat temp lobes, R insula, L calcarine cortex, R and L corpus striatum, R thalamus, cblr R lat lobe and vermis, rostral L pons | None |
6 | Occipital lobe, putamen, thalami, anterior perforated substance, cblr lat lobes, midbrain and pontine teg levels, basis pontis and bulbar levels | R temp fusiform gyrus |
7 | R lat temp lobe, R int capsule, cblr white matter, R pontine teg, L pontine locus coeruleus, multiple basis pontis levels | Cblr L lat lobe |
8 | L frontal lobe, white matter adjacent to tail of caudate nucleus, R hippocampus, cblr R lat lobe | None |
9 | R frontal lobe, L temp entorhinal cortex, R lat temp lobe, R parietal lobe, calcarine cortex, R thalamus, R putamen, int capsule, midbrain tectum, caudal midbrain, rostral basis pontis, substantia reticularis by inf olivary nucleus | R substantia nigra, caudal midbrain teg, R basis pontis |
10 | L frontal lobe; parietal lobes; L med temp lobe; R and L insula; L corpus striatum; thalami; lent nuclei; cblr lat lobes and vermis; rostral, mid-level, and caudal midbrain and pons; mid-level medulla | R lat temp lobe, R insula, L lent nuc, mid-level midbrain, pons, medulla |
11 | Parietal lobes, R and L insula, R and L corpus striatum, lenticular nuclei, thalami, int capsules, R rostral midbrain, L mid-level and caudal midbrain | L frontal lobe, L insula, L int capsule, L mid-level midbrain |
12 | R frontal lobe; lat and med temp lobes; R and L insula; L calcarine cortex; R and L corpus striatum; lent nuclei; thalami; cblr lat lobes and vermis; rostral, mid-level, and caudal midbrain and pons; rostral and mid-level medulla | Rostral pons |
13 | L frontal lobe, R calcarine cortex, L int capsule, cblr R lat lobe, mid-level midbrain, mid-level pons | None |
14 | Frontal, parietal, temp, insular, and calcarine cortex; R hippocampus; lent nuclei; thalami; caudate nuclei; int capsules; L external and extreme capsules; cblr lat lobes and vermis; middle cblr peduncle; midbrain; pontine teg and basis pontis; nuc of tractus solitarius area; nuclei of cranial nerves V and XII; inf vestibular nuclei; inf olivary nuclei; olivocerebellar tracts; pyramid | L globus pallidus interna |
15 | Frontal lobes, parietal lobes, R temp entorhinal cortex, L lat temp lobe, occipital lobes, R putamen, thalami, L basal forebrain, cblr R lat lobe, rostral and caudal midbrain, basis pontis | Rostral L basis pontis |
16 | Int capsules, R putamen, R thalamus | L putamen |
17 | L parietal lobe, R calcarine cortex, R corpus striatum, R int capsule | None |
18 | R frontal lobe, L parietal lobe | R lat temp lobe |
19 | R frontal lobe, L lat temp lobe, R thalamus, midbrain, mid-level and caudal basis pontis | None |
20 | R frontal orbital cortex; R lat temp lobe; L parietal lobe; L int capsule; cblr R lat lobe, dentate nuc, and middle cblr peduncle; caudal pons; rostral medulla; caudal bulbar pyramidal tract | R frontal orbital cortex, R thalamus, L lent nuc, L hypothalamus, rostral and caudal midbrain, pons |
21 | Frontal lobes, R parietal lobe, lat temp lobes, R med temp lobe, L int capsule, cblr L lat lobe, mid-level pons, mid-level medulla | Parietal lobes, R med temp lobe, L corpus striatum, R putamen, mid-level medulla |
22 | R frontal lobe; R lat temp lobe; L lat and med temp lobe; R and L insula; L thalamus; R int capsule; cblr lat lobes and vermis; caudal L midbrain; middle cblr peduncle; rostral, mid-level, and caudal pons and medulla | L lent nuc |
23 | Parietal lobes; R entorhinal cortex; R lat temp lobe; L insula; L calcarine cortex; R and L corpus striatum; thalami; cblr L lat lobe and vermis; caudal midbrain; rostral, mid-level, and caudal pons; mid-level and caudal medulla | R int capsule, cblr R lat lobe and vermis, mid- level pons |
24 | R med temp lobe, R putamen, mid-level pons | None |
25 | L parietal lobe, R lat and med temporal lobe, R caudate nuc, putamina, R thalamus, R midbrain teg and bilateral crus cerebri, L pontine teg, basis pontis | Rostral R midbrain, multiple L pontine levels |
26 | Cblr vermis, caudal pontine teg | None |
27 | L frontal lobe, L insula, R parietal lobe, cblr lat lobes and vermis, rostral R midbrain, mid-level pons, rostral medulla | None |
28 | L frontal lobe, L lat temp lobe, R and L insula, parietal lobes, R and L corpus striatum, lent nuclei, R claustrum, L thalamus, int capsules, cblr lat lobes, L middle cblr peduncle, R and L mid-level midbrain, rostral pontine teg and basis pontis, mid-level R and L basis pontis, caudal basis pontis, caudal medulla | R hypothalamus |
29 | L lat temp lobe, L insula, R calcarine cortex, head of L caudate nuc, rostral R pontine teg, caudal L pontine teg near superior vestibular nuc, mid-level medulla near lat reticular nuc | R supraoptic nuc |
30 | R parietal lobe, R calcarine cortex, L thalamus, rostral bulbar inf olivary nuc | R parietal lobe |
31 | Frontal lobes; L parietal lobe; L insula; L claustrum; extreme capsules; L corpus striatum; L globus pallidus; cblr L lat lobe and vermis; rostral, mid-level, and caudal pons; mid-level medulla | R frontal lobe, cblr lat lobes, rostral midbrain, mid-level and caudal pons, mid-level medulla |
32 | R frontal lobe, L parietal lobe, R corpus striatum, posterior thalami, cblr L lat lobe | R frontal lobe, R lent nuc, caudal L midbrain, rostral and mid-level pons |
33 | R frontal lobe, L temp and parietal lobes, L thalamus, L putamen, globus pallidus externa, cblr lat lobes, rostral and caudal R midbrain teg and substantia nigra, rostral L substantia nigra, caudal R crus cerebri, rostral R basis pontis, pyramidal tract | None |
34 | L frontal lobe; parietal lobes; R lat and med temp lobe; L lat temp lobe; R and L insula; R and L calcarine cortex; R and L corpus striatum; R hypothalamus; int capsules; cblr lat lobes and vermis; rostral L midbrain; mid-level midbrain crus cerebri and substantia nigra; caudal midbrain; rostral, mid-level, and caudal pons and medulla | Rostral L midbrain, mid- level R and L midbrain, inf cblr peduncle, caudal medulla |
35 | Frontal lobes, R parietal lobe, lat temp lobes, R and L insula, R and L corpus striatum, R lent nucleus, L thalamus, cblr vermis, caudal midbrain, mid-level and caudal pons | R basis pontis |
36 | L frontal lobe, R and L lateral temp lobes, R hippocampus, R parietal lobe, R ant comm, R thalamus, R lent nuc, L globus pallidus, internal capsules, R hypothalamus, cblr lat lobes, right substantia nigra, caudal crus cerebri, R rostral basis pontis, R and L mid-level and caudal basis pontis, R and L caudal pontine teg, bulbar reticular formation | L lat temp lobe, R midbrain teg |