Table 3 Immunohistochemical findings, fluorescence in situ hybridization (FISH) and In situ hybridization (ISH) tests of 11 patients with mucoepidermoid carcinoma (MEC)
Case no | Grade (AFIP) | Grade (Brandwein) | Necrosis | Histological features | P63 (%) | CK7 (%) | CK5/6 (%) | Ki-67 (%) | P16 (%) | HPV (ISH) | MAML2 (FISH) | EBER (ISH) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | Intermedia-grade | High-grade |  +  | conventional MEC | 4 +  | 3 +  | 4 +  | 3% | -(40%) | - |  +  | - |
2 | Low-grade | Intermedia-grade | - | conventional MEC | 1 +  | 4 +  | 4 +  | 3% | -(50%) | - |  +  | - |
3 | High-grade | High-grade | - | conventional MEC | 4 +  | 1 +  | 4 +  | 70% | -(0) | - |  +  | - |
4 | High-grade | High-grade |  +  | conventional MEC | 2 +  | 2 +  | 3 +  | focal 50% | -(0) | - |  +  | - |
5 | Low-grade | Low-grade | - | conventional MEC | 4 +  | 3 +  | 4 +  | 2% | -(10%) | - |  +  | - |
6 | Intermedia-grade | Intermedia-grade | - | clear cell MEC | 1 +  | 4 +  | 2 +  | 5% | -(10%) | - |  +  | - |
7 | Low-grade | Intermedia-grade | - | eosinophilic MEC | 2 +  | 4 +  | 4 +  | 4% | -(30%) |  +  |  +  | - |
8 | High-grade | High-grade |  +  | conventional MEC | 2 +  | 1 +  | 4 +  | focal 20% | -(20%) | - | - | - |
9 | Intermedia-grade | Intermedia-grade | - | conventional MEC | 4 +  | 1 +  | 4 +  | 8% | -(60%) | - | - | - |
10 | Intermedia-grade | Intermedia-grade | - | eosinophilic MEC | 2 +  | 4 +  | 4 +  | 6% | -(10%) | - | - | - |
11 | Low-grade | Intermedia-grade |  +  | conventional MEC | 2 +  | 3 +  | 3 +  | 15% |  + (80%) | - | - | - |