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Fig. 3 | Diagnostic Pathology

Fig. 3

From: An unusual case of primary splenic soft part alveolar sarcoma: case report and review of the literature with emphasis on the spectrum of TFE3-associated neoplasms

Fig. 3

Immunohistochemical and FISH analysis of the splenic tumour. A : Highly vascularized pattern between tumour nests highlighted by CD31 immunostaining. B : Nuclear diffuse TFE3 immunostaining of tumour cells. C-D : Heterogenous staining with Smooth muscle actin and Desmin antibodies. E : Illustration of TFE3 rearrangement in FISH. White arrows indicating break apart (split) signal in the majority of nuclei. F : PDL1 staining showing a weak to moderate but diffuse staining of tumour cells (TPS score > 90% and CPS score at 95). Bar scales indicate 100 μm for A, B and F, 40 μm for C-D

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Diagnostic Pathology

ISSN: 1746-1596

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